Mercedes-Benz E-Class — the model line, not this exact trim. Photo: Alexander Migl · CC BY-SA 4.0 · Wikimedia Commons

2027 Mercedes-Benz E350

Mercedes-Benz · Rear-Wheel Drive · 2.0 L 4-cyl turbo

See it on fueleconomy.gov

Model year2027

Combined MPG28

City MPG25

Highway MPG33

Annual fuel cost$2,950

Against the 105 fuel-efficient midsize cars

Combined MPG 28 MPGbest 55 · avg 31

Annual fuel cost $2,950best $1,200 · avg $2,715

Bars are scaled to the best in the list; the mark shows the list average. Lower is better for fuel cost; higher is better for the rest. All figures are the EPA's.

Summary

2027 Mercedes-Benz E350 by Mercedes-Benz. The figures below are from US EPA fueleconomy.gov, with the page each one came from.

Details

Model year: 2027fueleconomy.gov · 3 Oct 2026

Efficiency

Combined MPG: 28fueleconomy.gov · 3 Oct 2026
City MPG: 25fueleconomy.gov · 3 Oct 2026
Highway MPG: 33fueleconomy.gov · 3 Oct 2026

Running cost

Annual fuel cost: $2,950fueleconomy.gov · 3 Oct 2026
CO₂ (tailpipe): 316 g/mifueleconomy.gov · 3 Oct 2026

Car

Body: Carfueleconomy.gov · 3 Oct 2026
EPA class: Midsize Carsfueleconomy.gov · 3 Oct 2026
Drive: Rear-Wheel Drivefueleconomy.gov · 3 Oct 2026

Powertrain

Engine: 2.0 L 4-cyl turbofueleconomy.gov · 3 Oct 2026
Transmission: Automatic 9-spdfueleconomy.gov · 3 Oct 2026
Fuel: Gasolinefueleconomy.gov · 3 Oct 2026

More Mercedes-Benz cars

See the list

MB 2027 Mercedes-Benz AMG CLE53 4matic Plus (convertible) 2027 · All-Wheel Drive · 3.0 L 6-cyl turbo supercharged Combined MPG22Annual fuel cost$3,750 MB 2027 Mercedes-Benz AMG CLE53 4matic Plus (coupe) 2027 · All-Wheel Drive · 3.0 L 6-cyl turbo supercharged Combined MPG23Annual fuel cost$3,550

2027 Mercedes-Benz AMG G63 2027 · 4-Wheel Drive · 4.0 L 8-cyl turbo Combined MPG15Annual fuel cost$5,500

2027 Mercedes-Benz AMG GLC53 4matic Plus 2027 · All-Wheel Drive · 3.0 L 6-cyl turbo supercharged Combined MPG22Annual fuel cost$3,750

2027 Mercedes-Benz AMG GLC53 4matic Plus (coupe) 2027 · All-Wheel Drive · 3.0 L 6-cyl turbo supercharged Combined MPG22Annual fuel cost$3,750

2027 Mercedes-Benz AMG GT 43 (coupe) 2027 · Rear-Wheel Drive · 2.0 L 4-cyl turbo Combined MPG22Annual fuel cost$3,750

Where it ranks on CarCody

Mercedes-Benz Cars: Every Model and Year With MPG2118 listed
Most Fuel-Efficient Cars in 2026#152 of 402
Best Hybrid Cars in 2026#128 of 289
Most Fuel-Efficient Midsize Cars in 2026#57 of 105

Sources

fueleconomy.gov/feg/noframes/50495.shtml· checked 3 Oct 2026