Photo: Lexus IS by TTTNIS, CC0, via Wikimedia Commons. It shows the model, not always this exact version.
Lexus · model year 2026
2026 Lexus IS 350 AWD
Compact · All-Wheel Drive · Gas · EPA class: Compact Cars
Where it places
- 75 Fuel-efficient compact cars
Ordered by combined MPG #75 of 86 - 249 Fuel-efficient cars
Ordered by combined MPG #249 of 401 - 09 Lexus cars
Every model year, newest first #9 of 767 - 642 2026 cars and trucks
Every car of that year, A to Z #642 of 1,172 - 634 Fuel-efficient AWD and 4WD cars
Ordered by combined MPG #634 of 1,362 - 1410 Gas and hybrid cars by fuel cost
Ordered by fuel a year #1410 of 2,158
Against fuel-efficient compact cars
The CarCody take
The 2026 Lexus IS 350 AWD is a gasoline compact car with all-wheel drive and a 3.5-liter six-cylinder engine. Its EPA combined rating is 22 MPG, with 19 MPG in city driving and 26 MPG on the highway. The EPA lists annual fuel cost at $3,750 and tailpipe CO2 at 408 grams per mile.
Good to know
- All-wheel drive in a compact car
- 3.5 L six-cylinder gasoline engine
- 26 MPG highway rating
- Automatic S6 transmission
Watch for
- 19 MPG city rating
- 22 MPG combined rating
- EPA annual fuel cost of $3,750
- Tailpipe CO2 of 408 grams per mile
Who it suits. Drivers wanting a compact gasoline car with all-wheel drive Shoppers comparing EPA fuel figures for compact cars
The 2026 Lexus IS 350 AWD makes sense for someone seeking a compact, gasoline-powered car with all-wheel drive and a six-cylinder engine. Budget around the EPA's $3,750 annual fuel-cost figure, while recognizing that city driving is rated at 19 MPG and highway driving at 26 MPG. Its 22 combined MPG gives the simplest comparison point. If those numbers fit your driving and you want an automatic compact car, this Lexus matches the stated requirements without adding an electric-charging decision.
What it is
The 2026 Lexus IS 350 AWD is a compact car that runs on gasoline. It uses all-wheel drive, a 3.5 L six-cylinder engine, and an automatic S6 transmission.
Its defining EPA number is 22 combined MPG. That combines the car's 19 MPG city rating with its 26 MPG highway rating.
The numbers
The 19 MPG city figure fits stop-and-go driving, while 26 MPG is the highway figure. The combined result is 22 MPG.
The EPA lists tailpipe emissions at 408 grams of CO2 per mile.
What it costs to run
EPA annual fuel cost is $3,750.
How it compares
This IS 350 AWD sits in the EPA Compact Cars class and posts 22 combined MPG. You can place that figure beside other models in the fuel-efficient compact cars list or browse other Lexus cars.
Who it suits
It suits a buyer who wants a compact gasoline car with all-wheel drive and is comfortable with a 22 MPG combined rating.
The city and highway figures help if most of your driving falls clearly into one of those patterns.
Trade-offs
The 3.5 L six-cylinder engine and all-wheel-drive layout come with a 19 MPG city rating and a 26 MPG highway rating. Highway use is rated higher than city use.
This is a gasoline car, so its running-cost figure is tied to fuel use rather than electric charging.
Verdict
Choose the 2026 Lexus IS 350 AWD if your shortlist calls for a compact car, gasoline power, all-wheel drive, and an automatic transmission. Its central number is 22 combined MPG, with a listed annual fuel cost of $3,750. Drivers who spend more time on highways may see the 26 MPG rating, while city-heavy routes use the 19 MPG figure. The 408 grams-per-mile CO2 rating is another clear part of its operating profile.
Every figure on record
- Combined MPG
- 22 MPG
- City MPG
- 19 MPG
- Highway MPG
- 26 MPG
- Annual fuel cost
- $3,750
- Tailpipe CO₂
- 408 g per mile
- Model year
- 2026
- Body
- Car
- EPA size class
- Compact Cars
- Drive
- All-Wheel Drive
- Engine
- 3.5 L 6-cyl
- Transmission
- Automatic (S6)
- Fuel
- Gasoline
Questions
What is the 2026 Lexus IS 350 AWD's combined MPG?
The EPA combined rating is 22 MPG.
What are its city and highway MPG figures?
It is rated at 19 MPG in city driving and 26 MPG on the highway.
How much is its annual fuel cost?
The EPA lists annual fuel cost at $3,750.
What kind of drivetrain does it use?
The IS 350 AWD uses all-wheel drive.
What engine and transmission does it have?
It has a 3.5 L six-cylinder engine and an automatic S6 transmission.
What class is this Lexus?
The EPA classifies it as a Compact Car.
How much tailpipe CO2 does it produce?
Its tailpipe CO2 figure is 408 grams per mile.
Cars around it
2026 Mercedes-Benz AMG CLA45 S 4matic
23 MPG · $3,550 fuel a year
2027 Genesis G70 AWD
23 MPG · $3,550 fuel a year
2026 Cadillac CT4 V AWD
23 MPG · $3,550 fuel a year 2026 Lexus IS 350
22 MPG · $3,750 fuel a year
2026 Mercedes-Benz AMG C43 4matic
22 MPG · $3,750 fuel a year 2025 Lexus IS 300 AWD
22 MPG · $3,750 fuel a year
2025 Acura TLX Type-S
21 MPG · $3,900 fuel a year