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2022 Mercedes-Benz E450 4matic Coupe
Fuel economy & running costsHybrid
#401 of 2,118 · Mercedes-Benz cars

2022 Mercedes-BenzE450 4matic Coupe

Subcompact Cars · 4-Wheel Drive · 3.0 L 6-cyl turbo

24MPGcombined
21city
30highway
A year of fuel$3,400
CO₂ from the tailpipe362 g/mi
Figures from the EPA label (fueleconomy.gov), the same as on the car's window sticker.
See it on fueleconomy.gov

Against the 2,118 Mercedes-Benz cars

Combined MPG 24 MPGbest 33 · avg 20
Annual fuel cost $3,400best $600 · avg $4,245

Bars are scaled to the best in the list; the mark shows the list average. Lower is better for fuel cost; higher is better for the rest. All figures are the EPA's.

Safety ratings

Overall★★★★★
Frontal crash★★★★★
Side crash★★★★★
Rollover★★★★★
Recalls on record2

From NHTSA's 5-Star Safety Ratings for this model year (2022 Mercedes-Benz E-Class 4 DR 4WD).

Summary

2022 Mercedes-Benz E450 4matic Coupe by Mercedes-Benz. The figures below are from US EPA fueleconomy.gov, with the page each one came from.

Details

Model year
2022fueleconomy.gov · 3 Oct 2026

Efficiency

Combined MPG
24fueleconomy.gov · 3 Oct 2026
City MPG
21fueleconomy.gov · 3 Oct 2026
Highway MPG
30fueleconomy.gov · 3 Oct 2026

Running cost

Annual fuel cost
$3,400fueleconomy.gov · 3 Oct 2026
CO₂ (tailpipe)
362 g/mifueleconomy.gov · 3 Oct 2026

Car

Body
Carfueleconomy.gov · 3 Oct 2026
EPA class
Subcompact Carsfueleconomy.gov · 3 Oct 2026
Drive
4-Wheel Drivefueleconomy.gov · 3 Oct 2026

Powertrain

Engine
3.0 L 6-cyl turbofueleconomy.gov · 3 Oct 2026
Transmission
Automatic 9-spdfueleconomy.gov · 3 Oct 2026
Fuel
Gasolinefueleconomy.gov · 3 Oct 2026

More Mercedes-Benz cars

See the list
Mercedes-Benz #1 2027 · Mercedes-Benz AMG CLE53 4matic Plus (convertible) 22Combined MPG $3,750Fuel / year Mercedes-Benz #2 2027 · Mercedes-Benz AMG CLE53 4matic Plus (coupe) 23Combined MPG $3,550Fuel / year #3 2027 · Mercedes-Benz AMG G63 15Combined MPG $5,500Fuel / year #4 2027 · Mercedes-Benz AMG GLC53 4matic Plus 22Combined MPG $3,750Fuel / year #5 2027 · Mercedes-Benz AMG GLC53 4matic Plus (coupe) 22Combined MPG $3,750Fuel / year #6 2027 · Mercedes-Benz AMG GT 43 (coupe) 22Combined MPG $3,750Fuel / year

Listed on CarCody

Sources