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2022 Mercedes-Benz E350
Fuel economy & running costsGasoline
#396 of 2,118 · Mercedes-Benz cars

2022 Mercedes-BenzE350

Midsize Cars · Rear-Wheel Drive · 2.0 L 4-cyl turbo

26MPGcombined
23city
31highway
A year of fuel$3,150
CO₂ from the tailpipe342 g/mi
Figures from the EPA label (fueleconomy.gov), the same as on the car's window sticker.
See it on fueleconomy.gov

Against the 2,118 Mercedes-Benz cars

Combined MPG 26 MPGbest 33 · avg 20
Annual fuel cost $3,150best $600 · avg $4,245

Bars are scaled to the best in the list; the mark shows the list average. Lower is better for fuel cost; higher is better for the rest. All figures are the EPA's.

Safety ratings

Overall★★★★★
Frontal crash★★★★★
Side crash★★★★★
Rollover★★★★★
Recalls on record2

From NHTSA's 5-Star Safety Ratings for this model year (2022 Mercedes-Benz E-Class 4 DR RWD).

Summary

2022 Mercedes-Benz E350 by Mercedes-Benz. The figures below are from US EPA fueleconomy.gov, with the page each one came from.

Details

Model year
2022fueleconomy.gov · 3 Oct 2026

Efficiency

Combined MPG
26fueleconomy.gov · 3 Oct 2026
City MPG
23fueleconomy.gov · 3 Oct 2026
Highway MPG
31fueleconomy.gov · 3 Oct 2026

Running cost

Annual fuel cost
$3,150fueleconomy.gov · 3 Oct 2026
CO₂ (tailpipe)
342 g/mifueleconomy.gov · 3 Oct 2026

Car

Body
Carfueleconomy.gov · 3 Oct 2026
EPA class
Midsize Carsfueleconomy.gov · 3 Oct 2026
Drive
Rear-Wheel Drivefueleconomy.gov · 3 Oct 2026

Powertrain

Engine
2.0 L 4-cyl turbofueleconomy.gov · 3 Oct 2026
Transmission
Automatic 9-spdfueleconomy.gov · 3 Oct 2026
Fuel
Gasolinefueleconomy.gov · 3 Oct 2026

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See the list
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Listed on CarCody

Sources