Fuel economy & running costsHybrid

2025 Mercedes-BenzGLS580 4matic

Standard Sport Utility Vehicle 4WD · All-Wheel Drive · 4.0 L 8-cyl turbo

16MPGcombined

14city

19highway

A year of fuel$5,150

CO₂ from the tailpipe548 g/mi

Figures from the EPA label (fueleconomy.gov), the same as on the car's window sticker.

See it on fueleconomy.gov

Against the 2,118 Mercedes-Benz cars

Combined MPG 16 MPGbest 33 · avg 20

Annual fuel cost $5,150best $600 · avg $4,245

Bars are scaled to the best in the list; the mark shows the list average. Lower is better for fuel cost; higher is better for the rest. All figures are the EPA's.

Summary

The 2025 Mercedes-Benz GLS580 4matic is a gasoline SUV with all-wheel drive, a 4.0 L 8-cylinder turbo engine and an automatic 9-speed transmission. It is listed as hybrid. EPA fuel economy is 14 MPG in the city, 19 MPG on the highway and 16 MPG combined. Its listed annual fuel cost is USD 5,150, and tailpipe emissions are 548 g of CO2 per mile. The GLS580 4matic belongs to the GLS-Class family and uses GLS-Class as its base model. It is classified as a Standard Sport Utility Vehicle 4WD. For buyers comparing SUVs, these details show the model's stated powertrain and drive layout alongside fuel economy, emissions and annual fuel cost.

Who it is for

It suits SUV shoppers considering an all-wheel-drive model with a hybrid designation and 8-cylinder turbo engine. Buyers focused on running costs can factor in its fuel economy and annual fuel cost.

What is good

All-wheel drive
Hybrid designation
Automatic 9-speed transmission

What to know first

16 MPG combined
Annual fuel cost: USD 5,150
548 g CO2 per mile

CarCody review

2025 Mercedes-Benz GLS580 4matic: the full review

The GLS580 4matic pairs an 8-cylinder turbo gasoline engine with all-wheel drive. Its listed fuel economy, emissions and annual fuel cost are key considerations for buyers comparing running costs.

Overview

The 2025 Mercedes-Benz GLS580 4matic is a gasoline-powered, all-wheel-drive SUV with a 4.0-liter turbocharged V8 and a nine-speed automatic transmission. It is classified by the EPA as a Standard Sport Utility Vehicle 4WD. The model is listed as a hybrid, with an alternative fuel type of Hybrid; the provided specifications do not detail its hybrid system.

Its official EPA fuel economy is 16 mpg combined, with 14 mpg in city driving and 19 mpg on the highway. EPA-estimated annual fuel cost is $5,150, and tailpipe carbon dioxide emissions are 548 grams per mile. Those figures make fuel use a central consideration for buyers weighing this SUV's running costs.

Key features

Powertrain: 4.0-liter, eight-cylinder turbo engine paired with a nine-speed automatic transmission.
Drivetrain: All-wheel drive.
Fuel economy: 14 mpg city, 19 mpg highway and 16 mpg combined.
EPA classification: Standard Sport Utility Vehicle 4WD.
Hybrid designation: Listed as hybrid, with gasoline as its fuel.

Who it's for

The GLS580 4matic may suit buyers who want an all-wheel-drive SUV with a V8 engine and automatic transmission, and who are prepared to account for its fuel consumption. The EPA estimate of $5,150 in annual fuel cost offers a useful budget reference, though actual expenses vary with driving and fuel prices. Shoppers comparing vehicles on operating costs should weigh its 16-mpg combined rating alongside their expected city and highway use.

Its hybrid designation should not be read as evidence of a particular electric range or fuel-saving capability: no such details are included in the listed specifications. EV shoppers seeking range information will need specifications beyond those provided here.

Pros and cons

Pros

All-wheel drive is specified.
The engine, transmission, EPA class and city, highway and combined fuel economy figures are clearly stated.

Cons

EPA-estimated fuel economy is 16 mpg combined, including 14 mpg in city driving.
EPA-estimated annual fuel cost is $5,150.
The hybrid listing does not come with details about the system or electric operation.

Alternatives

For a broader look at the marque, see Mercedes-Benz cars. The provided alternatives are 2027 models and span several body styles: the 2027 Mercedes-Benz AMG G63, the 2027 Mercedes-Benz AMG GLC53 4matic Plus and its coupe, plus the 2027 Mercedes-Benz AMG CLE53 4matic Plus convertible and coupe. Other listed options include the 2027 Mercedes-Benz AMG GT 43 coupe, AMG GT 55 4matic Plus coupe and AMG GT 63 4matic Plus coupe. Fuel economy details for these alternatives are not provided here, so direct running-cost comparisons cannot be made.

Verdict

The 2025 Mercedes-Benz GLS580 4matic has a clearly specified V8 powertrain, nine-speed automatic and all-wheel drive, but its official fuel economy is modest: 16 mpg combined. Its $5,150 EPA annual fuel-cost estimate and 548 g-per-mile tailpipe CO2 figure are important considerations for buyers prioritizing running costs or emissions. The hybrid designation is present, but the available details do not explain what it means for operation or efficiency.