Fuel economy & running costsHybrid

2025 Mercedes-BenzGLS450 4matic

Standard Sport Utility Vehicle 4WD · All-Wheel Drive · 3.0 L 6-cyl turbo supercharged

21MPGcombined

19city

24highway

A year of fuel$3,900

CO₂ from the tailpipe428 g/mi

Figures from the EPA label (fueleconomy.gov), the same as on the car's window sticker.

See it on fueleconomy.gov

Against the 2,118 Mercedes-Benz cars

Combined MPG 21 MPGbest 33 · avg 20

Annual fuel cost $3,900best $600 · avg $4,245

Bars are scaled to the best in the list; the mark shows the list average. Lower is better for fuel cost; higher is better for the rest. All figures are the EPA's.

Summary

The 2025 Mercedes-Benz GLS450 4matic is a gasoline SUV with all-wheel drive, a 3.0 L 6-cylinder turbo supercharged engine and an automatic 9-speed transmission. It is listed as hybrid. EPA fuel economy is 19 MPG in the city, 24 MPG on the highway and 21 MPG combined. The annual fuel cost is USD 3,900, while tailpipe emissions are 428 g of CO2 per mile. The model belongs to the GLS-Class family and has GLS-Class as its base model. Its EPA classification is Standard Sport Utility Vehicle 4WD. Buyers comparing SUV powertrains and running costs can use these figures to weigh the GLS450 4matic's fuel use and emissions alongside its engine and drive configuration.

Who it is for

It suits SUV shoppers considering all-wheel drive, a hybrid designation and a 6-cylinder turbo supercharged engine. The listed fuel economy and annual cost help buyers account for ongoing fuel use.

What is good

24 MPG highway
21 MPG combined
All-wheel drive
Hybrid designation

What to know first

Annual fuel cost: USD 3,900
428 g CO2 per mile

CarCody review

2025 Mercedes-Benz GLS450 4matic: the full review

The GLS450 4matic combines an all-wheel-drive layout with a 6-cylinder turbo supercharged gasoline engine. Its 21 MPG combined rating and listed annual fuel cost offer useful running-cost context.

Overview

The 2025 Mercedes-Benz GLS450 4matic is a gasoline SUV with all-wheel drive, classified by the EPA as a Standard Sport Utility Vehicle 4WD. Its 3.0-liter, six-cylinder turbo-supercharged engine works with a nine-speed automatic transmission. The model is listed as a hybrid, while its fuel type is gasoline and its alternative fuel type is hybrid.

Official EPA fuel economy is 19 mpg in the city, 24 mpg on the highway and 21 mpg combined. The estimated annual fuel cost is $3,900, and tailpipe carbon dioxide emissions are 428 grams per mile. These figures offer a practical basis for comparing fuel use with other vehicles, though actual costs depend on driving and fuel prices.

Key features

Powertrain: 3.0 L six-cylinder turbo-supercharged engine with a nine-speed automatic transmission.
Drivetrain: All-wheel drive.
Fuel and hybrid classification: Gasoline fuel; listed as hybrid.
EPA economy: 19 city, 24 highway and 21 combined mpg.

Who it's for

The GLS450 4matic may suit shoppers who want a gasoline-powered, all-wheel-drive SUV and prioritize comparing official fuel economy and emissions figures. Buyers budgeting for fuel can use the EPA estimate of $3,900 per year as a reference, while recognizing that their own mileage and fuel prices will affect expenses. Its 21 mpg combined rating and 428 g/mi tailpipe CO2 figure are also relevant for shoppers weighing fuel consumption and emissions.

Pros and cons

Pros

All-wheel drive is specified.
EPA city, highway and combined mileage figures are available for comparison.
The listed annual fuel cost and tailpipe CO2 provide additional ownership-cost and emissions context.

Cons

The official combined rating is 21 mpg, with 19 mpg city and 24 mpg highway.
The EPA annual fuel-cost estimate is $3,900.
The listed specifications do not provide details about passenger capacity, cargo space, equipment or hybrid-system operation.

Alternatives

For more vehicles in the brand's lineup, browse Mercedes-Benz cars. The listed alternatives include the 2027 Mercedes-Benz AMG G63, along with the 2027 Mercedes-Benz AMG GLC53 4matic Plus and 2027 Mercedes-Benz AMG GLC53 4matic Plus (coupe). The list also includes the 2027 Mercedes-Benz AMG CLE53 4matic Plus (convertible), 2027 Mercedes-Benz AMG CLE53 4matic Plus (coupe), 2027 Mercedes-Benz AMG GT 43 (coupe), 2027 Mercedes-Benz AMG GT 55 4matic Plus (coupe) and 2027 Mercedes-Benz AMG GT 63 4matic Plus (coupe).

Verdict

The 2025 GLS450 4matic's documented profile is clear: a gasoline, hybrid-listed, all-wheel-drive SUV with a 3.0-liter six-cylinder turbo-supercharged engine and nine-speed automatic. Its official EPA rating is 21 mpg combined, and its estimated annual fuel cost is $3,900. Those figures make it possible to assess fuel use and emissions, but the available specifications do not establish equipment, cabin practicality or other ownership considerations.