Photo: Mercedes-Benz E-Class by Alexander Migl, CC BY-SA 4.0, via Wikimedia Commons. It shows the model, not always this exact version.
Mercedes-Benz · model year 2025
2025 Mercedes-Benz E450 4matic
Midsize · All-Wheel Drive · Hybrid · EPA class: Midsize Cars
EPA figures · 2025fueleconomy.gov
25MPG combined
22/31MPG city / highway
$3,300fuel a year
355 g CO₂ per mile 3.0 L 6-cyl turbo supercharged Automatic 9-spd
This car on fueleconomy.gov, read 2 October 2026. Your own figures depend on how and where you drive.
Where it places
Against fuel-efficient AWD and 4WD cars
Chart average 23 MPGBest 54 MPG
Lowest on the chart $1,250Chart average $3,611
Every figure on record
- Combined MPG
- 25 MPG
- City MPG
- 22 MPG
- Highway MPG
- 31 MPG
- Annual fuel cost
- $3,300
- Tailpipe CO₂
- 355 g per mile
- Model year
- 2025
- Body
- Car
- EPA size class
- Midsize Cars
- Drive
- All-Wheel Drive
- Engine
- 3.0 L 6-cyl turbo supercharged
- Transmission
- Automatic 9-spd
- Fuel
- Gasoline
Efficiency
Running cost
The car
Powertrain
Cars around it
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26 MPG · $3,150 fuel a year
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25 MPG · $3,300 fuel a year 2026 Volkswagen Golf R
25 MPG · $3,300 fuel a year 2025 Mercedes-Benz E450 4matic All-Terrain (wagon)
25 MPG · $3,300 fuel a year 2026 Mercedes-Benz E450 4matic All-Terrain (wagon)
25 MPG · $3,300 fuel a year 2027 Mercedes-Benz E450 4matic All-Terrain (wagon)
25 MPG · $3,300 fuel a year 2026 Mercedes-Benz E450 4matic
25 MPG · $3,300 fuel a year