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2025 Mercedes-Benz E350
Fuel economy & running costsHybrid
#168 of 2,118 · Mercedes-Benz cars

2025 Mercedes-BenzE350

Midsize Cars · Rear-Wheel Drive · 2.0 L 4-cyl turbo

28MPGcombined
25city
33highway
A year of fuel$2,950
CO₂ from the tailpipe316 g/mi
Figures from the EPA label (fueleconomy.gov), the same as on the car's window sticker.
See it on fueleconomy.gov

Against the 2,118 Mercedes-Benz cars

Combined MPG 28 MPGbest 33 · avg 20
Annual fuel cost $2,950best $600 · avg $4,245

Bars are scaled to the best in the list; the mark shows the list average. Lower is better for fuel cost; higher is better for the rest. All figures are the EPA's.

Summary

2025 Mercedes-Benz E350 by Mercedes-Benz. The figures below are from US EPA fueleconomy.gov, with the page each one came from.

Details

Model year
2025fueleconomy.gov · 3 Oct 2026

Efficiency

Combined MPG
28fueleconomy.gov · 3 Oct 2026
City MPG
25fueleconomy.gov · 3 Oct 2026
Highway MPG
33fueleconomy.gov · 3 Oct 2026

Running cost

Annual fuel cost
$2,950fueleconomy.gov · 3 Oct 2026
CO₂ (tailpipe)
316 g/mifueleconomy.gov · 3 Oct 2026

Car

Body
Carfueleconomy.gov · 3 Oct 2026
EPA class
Midsize Carsfueleconomy.gov · 3 Oct 2026
Drive
Rear-Wheel Drivefueleconomy.gov · 3 Oct 2026

Powertrain

Engine
2.0 L 4-cyl turbofueleconomy.gov · 3 Oct 2026
Transmission
Automatic 9-spdfueleconomy.gov · 3 Oct 2026
Fuel
Gasolinefueleconomy.gov · 3 Oct 2026

More Mercedes-Benz cars

See the list
Mercedes-Benz #1 2027 · Mercedes-Benz AMG CLE53 4matic Plus (convertible) 22Combined MPG $3,750Fuel / year Mercedes-Benz #2 2027 · Mercedes-Benz AMG CLE53 4matic Plus (coupe) 23Combined MPG $3,550Fuel / year #3 2027 · Mercedes-Benz AMG G63 15Combined MPG $5,500Fuel / year #4 2027 · Mercedes-Benz AMG GLC53 4matic Plus 22Combined MPG $3,750Fuel / year #5 2027 · Mercedes-Benz AMG GLC53 4matic Plus (coupe) 22Combined MPG $3,750Fuel / year #6 2027 · Mercedes-Benz AMG GT 43 (coupe) 22Combined MPG $3,750Fuel / year

Listed on CarCody

Sources