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2025 Lexus IS 350
Lexus IS — the model line, not this exact trim. Photo: TTTNIS · CC0 · Wikimedia Commons

2025 Lexus IS 350

Lexus · Rear-Wheel Drive · 3.5 L 6-cyl

★★★★★ NHTSA overall safety

See it on fueleconomy.gov
Model year2025
Combined MPG23
City MPG20
Highway MPG28
Annual fuel cost$3,550

Against the 767 lexus cars

Combined MPG 23 MPGbest 46 · avg 23
Annual fuel cost $3,550best $600 · avg $3,551

Bars are scaled to the best in the list; the mark shows the list average. Lower is better for fuel cost; higher is better for the rest. All figures are the EPA's.

Safety ratings

Overall★★★★★
Frontal crash★★★★★
Side crash★★★★★
Rollover★★★★★
Recalls on record0

From NHTSA's 5-Star Safety Ratings for this model year (2025 Lexus IS 350 4 DR RWD).

Summary

2025 Lexus IS 350 by Lexus. The figures below are from US EPA fueleconomy.gov, with the page each one came from.

Details

Model year
2025fueleconomy.gov · 3 Oct 2026

Efficiency

Combined MPG
23fueleconomy.gov · 3 Oct 2026
City MPG
20fueleconomy.gov · 3 Oct 2026
Highway MPG
28fueleconomy.gov · 3 Oct 2026

Running cost

Annual fuel cost
$3,550fueleconomy.gov · 3 Oct 2026
CO₂ (tailpipe)
385 g/mifueleconomy.gov · 3 Oct 2026

Car

Body
Carfueleconomy.gov · 3 Oct 2026
EPA class
Compact Carsfueleconomy.gov · 3 Oct 2026
Drive
Rear-Wheel Drivefueleconomy.gov · 3 Oct 2026

Powertrain

Engine
3.5 L 6-cylfueleconomy.gov · 3 Oct 2026
Transmission
Automatic (S8)fueleconomy.gov · 3 Oct 2026
Fuel
Gasolinefueleconomy.gov · 3 Oct 2026

More lexus cars

See the list
2026 Lexus ES 350e (19 inch Wheels) 2026 · Front-Wheel Drive · 167 kW AC Synchronous Combined MPGe127EPA range307 miAnnual fuel cost$600 2026 Lexus ES 350e (21 inch Wheels) 2026 · Front-Wheel Drive · 167 kW AC Synchronous Combined MPGe121EPA range292 miAnnual fuel cost$600 2026 Lexus ES 350h 2026 · Front-Wheel Drive · 2.5 L 4-cyl Combined MPG46Annual fuel cost$1,800 2026 Lexus ES 350h AWD 2026 · All-Wheel Drive · 2.5 L 4-cyl Combined MPG44Annual fuel cost$1,850 2026 Lexus ES 500e AWD (19 inch Wheels) 2026 · All-Wheel Drive · 88 and 167 kW AC Synchronous Combined MPGe114EPA range276 miAnnual fuel cost$700 2026 Lexus ES 500e AWD (21 inch Wheels) 2026 · All-Wheel Drive · 88 and 167 kW AC Synchronous Combined MPGe112EPA range272 miAnnual fuel cost$700

Listed on CarCody

Sources