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2022 Lexus RX 350
Lexus RX — the model line, not this exact trim. Photo: Mr.choppers · CC BY-SA 3.0 · Wikimedia Commons

2022 Lexus RX 350

Lexus · Front-Wheel Drive · 3.5 L 6-cyl

★★★★☆ NHTSA overall safety

See it on fueleconomy.gov
Model year2022
Combined MPG23
City MPG20
Highway MPG27
Annual fuel cost$2,900

Against the 767 lexus cars

Combined MPG 23 MPGbest 46 · avg 23
Annual fuel cost $2,900best $600 · avg $3,551

Bars are scaled to the best in the list; the mark shows the list average. Lower is better for fuel cost; higher is better for the rest. All figures are the EPA's.

Safety ratings

Overall★★★★★
Frontal crash★★★★★
Side crash★★★★★
Rollover★★★★★
Recalls on record0

From NHTSA's 5-Star Safety Ratings for this model year (2022 Lexus RX 350 SUV FWD).

Summary

2022 Lexus RX 350 by Lexus. The figures below are from US EPA fueleconomy.gov, with the page each one came from.

Details

Model year
2022fueleconomy.gov · 3 Oct 2026

Efficiency

Combined MPG
23fueleconomy.gov · 3 Oct 2026
City MPG
20fueleconomy.gov · 3 Oct 2026
Highway MPG
27fueleconomy.gov · 3 Oct 2026

Running cost

Annual fuel cost
$2,900fueleconomy.gov · 3 Oct 2026
CO₂ (tailpipe)
391 g/mifueleconomy.gov · 3 Oct 2026

Car

Body
SUVfueleconomy.gov · 3 Oct 2026
EPA class
Small Sport Utility Vehicle 2WDfueleconomy.gov · 3 Oct 2026
Drive
Front-Wheel Drivefueleconomy.gov · 3 Oct 2026

Powertrain

Engine
3.5 L 6-cylfueleconomy.gov · 3 Oct 2026
Transmission
Automatic (S8)fueleconomy.gov · 3 Oct 2026
Fuel
Gasolinefueleconomy.gov · 3 Oct 2026

More lexus cars

See the list
2026 Lexus ES 350e (19 inch Wheels) 2026 · Front-Wheel Drive · 167 kW AC Synchronous Combined MPGe127EPA range307 miAnnual fuel cost$600 2026 Lexus ES 350e (21 inch Wheels) 2026 · Front-Wheel Drive · 167 kW AC Synchronous Combined MPGe121EPA range292 miAnnual fuel cost$600 2026 Lexus ES 350h 2026 · Front-Wheel Drive · 2.5 L 4-cyl Combined MPG46Annual fuel cost$1,800 2026 Lexus ES 350h AWD 2026 · All-Wheel Drive · 2.5 L 4-cyl Combined MPG44Annual fuel cost$1,850 2026 Lexus ES 500e AWD (19 inch Wheels) 2026 · All-Wheel Drive · 88 and 167 kW AC Synchronous Combined MPGe114EPA range276 miAnnual fuel cost$700 2026 Lexus ES 500e AWD (21 inch Wheels) 2026 · All-Wheel Drive · 88 and 167 kW AC Synchronous Combined MPGe112EPA range272 miAnnual fuel cost$700

Listed on CarCody

Sources