Get listed
Mercedes-Benz S-Class

Photo: Mercedes-Benz S-Class by David Adam Kess, CC BY-SA 4.0, via Wikimedia Commons. It shows the model, not always this exact version.

Mercedes-Benz · model year 2021

2021 Mercedes-Benz S580 4matic

Large · 4-Wheel Drive · Hybrid · EPA class: Large Cars

EPA figures · 2021fueleconomy.gov
20MPG combined
17/25MPG city / highway
$4,100fuel a year
452 g CO₂ per mile 4.0 L 8-cyl turbo Automatic 9-spd
This car on fueleconomy.gov, read 2 October 2026. Your own figures depend on how and where you drive.

Where it places

Every figure on record

Efficiency
Combined MPG
20 MPG
City MPG
17 MPG
Highway MPG
25 MPG
Running cost
Annual fuel cost
$4,100
Tailpipe CO₂
452 g per mile
The car
Model year
2021
Body
Car
EPA size class
Large Cars
Drive
4-Wheel Drive
Powertrain
Engine
4.0 L 8-cyl turbo
Transmission
Automatic 9-spd
Fuel
Gasoline

More Mercedes-Benz model years

Every alternative to the 2021 Mercedes-Benz S580 4matic →